Article
Volumes of hippocampus, amygdala and frontal lobe in Alzheimer patients with different apolipoprotein E genotypes.
Neuroscience - 1 Jul 1995
Lehtovirta M, Laakso M P, Soininen H, Helisalmi S, Mannermaa A, Helkala E L, Partanen K, Ryynänen M, Vainio P, Hartikainen P
Abstract excerpt
An increased frequency of apolipoprotein E E4 allele has been reported in patients with late onset Alzheimer's disease. Apolipoprotein E participates in the transport of cholesterol and other lipids and interferes with the growth and regeneration of both peripheral and central nervous system tiss...
Topics
- Aged
- Alzheimer Disease
- Amygdala
- Apolipoproteins E
- Cognition
- DNA Restriction Enzymes
- Female
- Frontal Lobe
- Genotype
- Hippocampus
- Humans
- Magnetic Resonance Imaging
- Male
- Memory
- Polymerase Chain Reaction