Article
A role for thymic stromal lymphopoietin in CD4(+) T cell development.
The Journal of experimental medicine - 19 Jul 2004
Al-Shami Amin, Spolski Rosanne, Kelly John, Fry Terry, Schwartzberg Pamela L, Pandey Akhilesh, Mackall Crystal L, Leonard Warren J
Abstract excerpt
Thymic stromal lymphopoietin (TSLP) signals via a receptor comprising the interleukin (IL)-7 receptor alpha chain and a distinctive subunit, TSLP receptor (TSLPR), which is most related to the common cytokine receptor gamma chain, gamma(c). We have generated TSLPR knockout (KO) mice and found that although these mice had normal lymphocyte numbers, gamma(c)/TSLPR double KO mice had a greater lymphoid defect than...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.