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Article

Development of regulatory T cells requires IL-7Ralpha stimulation by IL-7 or TSLP.

Blood - 15 Oct 2008

Mazzucchelli Renata, Hixon Julie A, Spolski Rosanne, Chen Xin, Li Wen Qing, Hall Veronica L, Willette-Brown Jami, Hurwitz Arthur A, Leonard Warren J, Durum Scott K

Abstract excerpt

Interleukin-7 (IL-7), a cytokine produced by stromal cells, is required for thymic development and peripheral homeostasis of most major subsets of T cells. We examined whether regulatory T (Treg) cells also required the IL-7 pathway by analyzing IL-7Ralpha(-/-) mice. We observed a striking reduct...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18664628
DOI: 10.1182/blood-2008-02-137414
PMCID: PMC2569178

Genes

TSLP
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18664628-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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