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The IL-7 Signaling Pathway Regulates Lymph Node Development Independent of Peripheral Lymphocytes

5 Mar 2010

Abstract excerpt

Lymph node (LN) organogenesis is initiated by the interaction between hematopoietic lymphoid tissue inducer (LTi) cells and the mesenchymal organizer cells. Mice in which the IL-7 signaling pathway has been disrupted have a severe defect in LN development; however, the reasons underlying this defect are as yet unknown. In this study, we show that the overexpression of thymic stromal lymphopoietin (TSLP) increased...

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PMID: 20207995
DOI: 10.4049/jimmunol.0901647

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