Article
Interleukin-7 receptor alpha (IL-7Ralpha) deficiency: cellular and molecular bases. Analysis of clinical, immunological, and molecular features in 16 novel patients.
Immunological reviews - 1 Feb 2005
Giliani Silvia, Mori Luigi, de Saint Basile Geneviève, Le Deist Francoise, Rodriguez-Perez Carmen, Forino Concetta, Mazzolari Evelina, Dupuis Sophie, Elhasid Ronit, Kessel Aharon, Galambrun Claire, Gil Juana, Fischer Alain, Etzioni Amos, Notarangelo Luigi D
Abstract excerpt
Analysis of gene-targeted mice and patients with severe combined immunodeficiency due to mutations of the alpha chain of the interleukin-7 receptor (IL-7Ralpha) has shown important differences between mice and humans in the role played by IL-7 in lymphoid development. More recently, it has been shown that IL-7Ralpha is also shared by the receptor for another cytokine, thymic stromal lymphopoietin (TSLP). In this...
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