Article
Stat5a/b are essential for normal lymphoid development and differentiation.
Proceedings of the National Academy of Sciences of the United States of America - 24 Jan 2006
Yao Zhengju, Cui Yongzhi, Watford Wendy T, Bream Jay H, Yamaoka Kunihiro, Hissong Bruce D, Li Denise, Durum Scott K, Jiang Qiong, Bhandoola Avinash, Hennighausen Lothar, O'Shea John J
Abstract excerpt
Cytokines that use the common gamma chain gammac are critical for lymphoid development and function. Mutations of the IL-7 receptor, gammac, or its associated kinase, Jak3, are the major cause of human severe combined immunodeficiency. Although activated by IL-7, Stat5a/b (Stat, signal transducer and activator of transcription) have been thought to play limited roles in lymphoid development. However, we now show...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.