Article
CLIPR-59 is a lipid raft-associated protein containing a cytoskeleton-associated protein glycine-rich domain (CAP-Gly) that perturbs microtubule dynamics.
The Journal of biological chemistry - 24 Sept 2004
Lallemand-Breitenbach Valérie, Quesnoit Mélanie, Braun Virginie, El Marjou Ahmed, Poüs Christian, Goud Bruno, Perez Franck
Abstract excerpt
We recently have identified a new cytoplasmic linker protein (CLIP), CLIPR-59, which is involved in the regulation of early endosome/trans-Golgi network dynamics. In contrast with CLIP-170, CLIPR-59 is not localized to microtubules at steady state but is associated with the trans-Golgi network and the plasma membrane. Here we show that the last 30 amino acids (C30) are sufficient for membrane targeting and that...
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