Altered binding of mutated presenilin with cytoskeleton-interacting proteins.

doi:10.1016/s0014-5793(99)01664-6

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Article

Altered binding of mutated presenilin with cytoskeleton-interacting proteins.

FEBS letters - 7 Jan 2000

Johnsingh A A, Johnston J M, Merz G, Xu J, Kotula L, Jacobsen J S, Tezapsidis N

Abstract excerpt

The majority of familial Alzheimer's disease (AD) cases are linked to mutations on presenilin 1 and 2 genes (PS1 and PS2). The normal function of the proteins and the mechanisms underlying early-onset AD are currently unknown. To address this, we screened an expression library for proteins that bind differentially to the wild-type PS1 and mutant in the large cytoplasmic loop (PS1L). Thus we isolated the...

Topics

Alzheimer Disease
Conserved Sequence
Cytoskeleton
Humans
Intermediate Filament Proteins
Ionomycin
Membrane Proteins
Microtubule-Associated Proteins
Mutation
Neoplasm Proteins
Peptide Library
Precipitin Tests
Presenilin-1
Reed-Sternberg Cells
Thapsigargin

Source

Open in PubMed

Identifiers

PMID: 10620705
DOI: 10.1016/s0014-5793(99)01664-6

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