Article
CLIP-170 interacts with dynactin complex and the APC-binding protein EB1 by different mechanisms.
Cell motility and the cytoskeleton - 1 Jul 2003
Goodson Holly V, Skube Susan B, Stalder Romaine, Valetti Caterina, Kreis Thomas E, Morrison Ewan E, Schroer Trina A
Abstract excerpt
CLIP-170 is a "cytoplasmic linker protein" implicated in endosome-microtubule interactions and in control of microtubule dynamics. CLIP-170 localizes dynamically to growing microtubule plus ends, colocalizing with the dynein activator dynactin and the APC-binding protein EB1. This shared "plus-end tracking" behavior suggests that CLIP-170 might interact with dynactin and/or EB1. We have used site-specific...
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