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Article

Chk1 suppresses bypass of mitosis and tetraploidization in p53-deficient cancer cells.

Cell cycle (Georgetown, Tex.) - 15 Apr 2012

Wilsker Deborah, Chung Jon H, Bunz Fred

Abstract excerpt

Many cancer cells are unable to maintain a numerically stable chromosome complement. It is well established that aberrant cell division can generate progeny with increased ploidy, but the genetic factors required for maintenance of diploidy are not well understood. Using an isogenic model system derived by gene targeting, we examined the role of Chk1 in p53-proficient and -deficient cancer cells. Targeted...

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Share to Ataxia Telangiectasia Mutated Proteins
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Source

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Identifiers

PMID: 22433954
DOI: 10.4161/cc.19944
PMCID: PMC3341228

Genes

ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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