Article
Splenic CD4+ T cells have a distinct transcriptional response six hours after the onset of sepsis.
Journal of the American College of Surgeons - 1 Sept 2006
McDunn Jonathan E, Turnbull Isaiah R, Polpitiya Ashoka D, Tong Alice, MacMillan Sandra K, Osborne Dale F, Hotchkiss Richard S, Colonna Marco, Cobb J Perren
Abstract excerpt
BACKGROUND: In animal and human autopsy studies of sepsis, CD4+ splenocytes either undergo apoptosis or are polarized to the Th2 effector subtype. In mice, these changes occur within 24 hours of the onset of sepsis. Preventing the loss of CD4+ T cells and the Th2-polarization of CD4+ T cells provides a significant survival advantage in mouse models of sepsis. The molecular mechanism(s) for the phenotypic changes...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.