Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inverse metabolic engineering with phosphagen kinase systems improves the cellular energy state.

Metabolic engineering - 1 Jul 2004

Sauer Uwe, Schlattner Uwe

Abstract excerpt

Inverse metabolic engineering attempts to identify or construct desired phenotypes of applied interest to endow them on appropriate host organisms. A particular desirable phenotype is the ATP homeostasis exhibited by animal cells with high and variable ATP turnover through temporal and spatial energy buffering. This buffering is achieved by phosphagen kinase systems that consist of a specific kinase and its...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphate
Share to Energy Metabolism
Share to Gene Expression Regulation, Enzymologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Enhancement

Share to Phenotype

Share to Phosphotransferases

Share to Protein Engineering

Share to Recombinant Proteins

Source

Identifiers

PMID: 15256212
DOI: 10.1016/j.ymben.2003.11.004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inverse metabolic engineering with phosphagen kinase systems improves the cellular energy state.PMID 15256212Read ↗

Inverse metabolic engineering: a strategy for directed genetic engineering of useful phenotypes.Semantic proximity Read ↗

Genetically encoded tool for manipulation of ATP/ADP ratio in human cellsSemantic proximity Read ↗

Reflections on the scope and the future of metabolic engineering and its connections to functional genomics and drug discovery.Semantic proximity Read ↗

Mitochondrial respiration is required to provide amino acids during fermentative proliferation of fission yeastSemantic proximity Read ↗

Efficient protein production by yeast requires global tuning of metabolism.Semantic proximity Read ↗

Polyphosphate synthesis is essential for phosphate and ATP homeostasis during nutrient upshift.Semantic proximity Read ↗

Enabling inverse metabolic engineering through genomics.Semantic proximity Read ↗

ATPLyzer – An advanced ratiometric multi-colour biosensor for long-term monitoring of ATP dynamicsSemantic proximity Read ↗

Pathway swapping: Toward modular engineering of essential cellular processes.Semantic proximity Read ↗

Intervention with metabolites emulating endogenous cell transitions accelerates muscle regeneration in young and aged miceSemantic proximity Read ↗

Reduced Glucose Sensation Can Increase the Fitness of <i>Saccharomyces cerevisiae</i> Lacking Mitochondrial DNASemantic proximity Read ↗

After a decade of progress, an expanded role for metabolic engineering.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.