Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polyphosphate synthesis is essential for phosphate and ATP homeostasis during nutrient upshift.

Proceedings of the National Academy of Sciences of the United States of America - 9 Jun 2026

White Maria L, Mortier Julien, Granqvist Lova, Omnus Deike J, Louski Max, Crang Nick, Aldikacti Berent, Migeot Valérie, Chien Peter, Hennequart Marc, Hallez Régis, Jonas Kristina

Abstract excerpt

Inorganic polyphosphate (polyP) is a ubiquitous molecule found across all domains of life. Although implicated in diverse cellular processes, including phosphate storage, stress responses, and pathogenicity, loss of polyP synthesis typically causes only mild growth defects. Here, we demonstrate an essential physiological role for polyP synthesis during recovery from phosphate starvation, when cells transition...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphate
Share to Bacterial Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Caulobacter crescentus

Share to Homeostasis

Share to Nutrients

Share to Phosphates

Share to Phosphotransferases (Phosphate Group Acceptor)

Share to Polyphosphates

Source

Identifiers

PMID: 42234530
DOI: 10.1073/pnas.2531128123

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 17 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polyphosphate synthesis is essential for phosphate and ATP homeostasis during nutrient upshift.PMID 42234530Read ↗

Mutations in Escherichia coli Polyphosphate Kinase That Lead to Dramatically Increased In Vivo Polyphosphate Levels.Semantic proximity Read ↗

Polyphosphate Kinase 2 (PPK2) Enzymes: Structure, Function, and Roles in Bacterial Physiology and VirulenceSemantic proximity Read ↗

Chromosome replication and segregation govern the biogenesis and inheritance of inorganic polyphosphate granulesSemantic proximity Read ↗

Systematic screening of polyphosphate (poly P) levels in yeast mutant cells reveals strong interdependence with primary metabolism.Semantic proximity Read ↗

Limitation of phosphate assimilation maintains cytoplasmic magnesium homeostasis.Semantic proximity Read ↗

Identification of polyphosphate-binding proteins in <i>E. coli</i> uncovers targets involved in translation control and ribosome biogenesisSemantic proximity Read ↗

A broad response to intracellular long-chain polyphosphate in human cellsSemantic proximity Read ↗

Multi-level evaluation of Escherichia coli polyphosphate related mutants using global transcriptomic, proteomic and phenomic analyses.Semantic proximity Read ↗

Inorganic Polyphosphate Accumulation in Escherichia coli Is Regulated by DksA but Not by (p)ppGppSemantic proximity Read ↗

Identification of the PhoB Regulon and Role of PhoU in the Phosphate Starvation Response of Caulobacter crescentus.Semantic proximity Read ↗

RNA degradation by ribonuclease T2 is required for phosphate homeostasis in <i>S. cerevisiae</i>Semantic proximity Read ↗

The archaeal family 3 polyphosphate kinase reveals a function of polyphosphate as energy buffer under low energy chargeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.