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Article

Intervention with metabolites emulating endogenous cell transitions accelerates muscle regeneration in young and aged mice

1 Mar 2024

Abstract excerpt

Tissue regeneration following an injury requires dynamic cell-state transitions that allow for establishing the cell identities required for the restoration of tissue homeostasis and function. Here, we present a biochemical intervention that induces an intermediate cell state mirroring a transition identified during normal differentiation of myoblasts and other multipotent and pluripotent cells to mature cells....

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Identifiers

PMID: 38508141
DOI: 10.1016/j.xcrm.2024.101449

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