Article
The effect of oxidative metabolism on spontaneous Pol zeta-dependent translesion synthesis in Saccharomyces cerevisiae.
DNA repair - 3 Feb 2006
Minesinger Brenda K, Abdulovic Amy L, Ou Tingwei M, Jinks-Robertson Sue
Abstract excerpt
DNA lesions can stall or block high-fidelity polymerases, thus inhibiting replication. To bypass such lesions, low-fidelity translesion synthesis (TLS) polymerases can be used to insert a nucleotide across from the lesion or extend from a lesion:base mispair. When DNA repair is compromised in Sac...
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