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Article

ISL1 Directly Regulates FGF10 Transcription during Human Cardiac Outflow Formation

27 Jan 2012

Abstract excerpt

The LIM homeodomain gene Islet-1 (ISL1) encodes a transcription factor that has been associated with the multipotency of human cardiac progenitors, and in mice enables the correct deployment of second heart field (SHF) cells to become the myocardium of atria, right ventricle and outflow tract. Other markers have been identified that characterize subdomains of the SHF, such as the fibroblast growth factor Fgf10 in...

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PMID: 22303449
DOI: 10.1371/journal.pone.0030677

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