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Article

Proteolytic stress: A unifying concept for the etiopathogenesis of Parkinson's disease

1 Jan 2003

Abstract excerpt

The etiopathogenesis of Parkinson's disease (PD) has been elusive. Recently, several lines of evidence have converged to suggest that defects in the ubiquitin-proteasome system and proteolytic stress underlie nigral pathology in both familial and sporadic forms of the illness. In support of this concept, mutations in alpha-synuclein that cause the protein to misfold and resist proteasomal degradation cause...

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Share to Cellular transport and secretion
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PMID: 12666100
DOI: 10.1002/ana.10512

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