Article
A continuum model for tumour suppression.
Nature - 10 Aug 2011
Berger Alice H, Knudson Alfred G, Pandolfi Pier Paolo
Abstract excerpt
This year, 2011, marks the forty-year anniversary of the statistical analysis of retinoblastoma that provided the first evidence that tumorigenesis can be initiated by as few as two mutations. This work provided the foundation for the two-hit hypothesis that explained the role of recessive tumour suppressor genes (TSGs) in dominantly inherited cancer susceptibility syndromes. However, four decades later, it is...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.