Population genetics of tumor suppressor genes.

Abstract excerpt

Cancer emerges when a single cell receives multiple mutations. For example, the inactivation of both alleles of a tumor suppressor gene (TSG) can imply a net reproductive advantage of the cell and might lead to clonal expansion. In this paper, we calculate the probability as a function of time that a population of cells has generated at least one cell with two inactivated alleles of a TSG. Different kinetic laws...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Neoplasms
• Share to Alleles
• Share to Evolution, Molecular