Comparison of the expression of a mutant dihydrofolate reductase under control of different internal promoters in retroviral vectors.

doi:10.1089/hum.1992.3.4-381

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Article

Comparison of the expression of a mutant dihydrofolate reductase under control of different internal promoters in retroviral vectors.

Human gene therapy - 1 Aug 1992

Li M, Hantzopoulos P A, Banerjee D, Zhao S C, Schweitzer B I, Gilboa E, Bertino J R

Abstract excerpt

To determine the effect of different promoters on the expression of an altered dihydrofolate reductase (DHFR) gene conferring methotrexate (MTX) resistance in different cell types, double-copy retroviral vectors were constructed carrying a murine mutant DHFR under the control of five different pr...

Topics

3T3 Cells
Animals
Blotting, Northern
Bone Marrow Cells
Drug Resistance
Gene Expression Regulation, Enzymologic
Genetic Vectors
Humans
Leukemia
Methotrexate
Mice
Moloney murine leukemia virus
Mutation
Promoter Regions, Genetic
Tetrahydrofolate Dehydrogenase
Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 1525211
DOI: 10.1089/hum.1992.3.4-381

Genes

DHFR
ADA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1525211-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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