Article
Retroviral transduction of human CD34+ umbilical cord blood progenitor cells with a mutated dihydrofolate reductase cDNA.
Human gene therapy - 1 Jan 1998
Flasshove M, Banerjee D, Leonard J P, Mineishi S, Li M X, Bertino J R, Moore M A
Abstract excerpt
Umbilical cord blood cells (UCB) have become a major target population for experimental and clinical studies using transfer of genes involved in inborn enzymatic diseases. Cord blood contains hematopoietic progenitor cells at a high frequency, and expanding these cells ex vivo generates sufficient numbers of hematopoietic precursors for transplantation into adults, e.g., as supportive treatment. As clinical...
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