Article
The FcgammaRIIa polymorphism in patients with chronic kidney graft rejection.
Transplantation proceedings - 1 Jun 2004
Pawlik A, Florczak M, Bak L, Dabrowska-Zamojcin E, Rozanski J, Domanski L, Gawronska-Szklarz B
Abstract excerpt
The FcgammaRIIa receptors, which provide a crucial link between cellular and humoral components of the immune response, display allelic polymorphism. Individuals are homozygous for either arginine 131 (RR131) or histidine 131 (HH131) or are heterozygous for these two alleles (RH131). The HH131 genotype binds human IgG2 with high RR131 with low, and RH131 with intermediate affinity. The aim of the study was to...
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