Article
Polymorphism of the FcgammaRIIalpha IgG receptor in patients with lupus nephritis and glomerulopathy.
The Journal of rheumatology - 1 Mar 2006
Gelmetti Adriana Peixoto, Freitas Antônio Carlos, Woronik Viktoria, Barros Rui Toledo, Bonfá Eloísa, Monteiro Renato Costa
Abstract excerpt
OBJECTIVE: FcgammaRIIalpha is a low affinity receptor that has 2 codominantly expressed alleles, R131 and H131, which differ in their ability to bind immunoglobulin G (IgG) subclasses. Cells expressing H131 bind more efficiently complexed IgG2 than those expressing the R131 variant. The FcgammaRIIalpha polymorphism has been shown to be associated with lupus nephritis. We evaluated the relevance of FcgammaRIIalpha...
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