Rapid detection of the Fc gamma RIIA-H/R 131 ligand-binding polymorphism using an allele-specific restriction enzyme digestion (ASRED).

doi:10.1016/s0022-1759(96)00164-0

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Article

Rapid detection of the Fc gamma RIIA-H/R 131 ligand-binding polymorphism using an allele-specific restriction enzyme digestion (ASRED).

Journal of immunological methods - 29 Nov 1996

Jiang X M, Arepally G, Poncz M, McKenzie S E

Abstract excerpt

A polymorphism of the gene for Fc gamma RIIA, arginine (R) or histidine (H) at position 131, alters the ability of the receptor to bind certain IgG subclasses. Identification of the Fc gamma RIIA-H/R 131 genotype has assumed increasing importance in disorders of host defense, immunohematologic di...

Topics

Alleles
Arginine
DNA Restriction Enzymes
Histidine
Humans
Ligands
Polymorphism, Genetic
Receptors, IgG

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