Article
Pneumococcal vaccine efficacy for mucosal pneumococcal infections depends on Fcgamma receptor IIa polymorphism.
Vaccine - 6 Feb 2006
Wiertsema Selma P, Veenhoven Reinier H, Walraven Vanessa, Uiterwaal Cuno S P M, Schilder Anne G M, Rijkers Ger T, Sanders Elisabeth A M
Abstract excerpt
IgG2 antibodies are the main antibody subclass produced after pneumococcal polysaccharide vaccination. For these antibodies to be effective, interaction with FcgammaIIa receptors on phagocytic cells is necessary. FcgammaRIIa displays a functional polymorphism with either a histidine (H) or arginine (R) at position 131. Interaction of IgG2 antibodies depends on the H131 allele, whereas this interaction is low to...
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