Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Anti-topoisomerase II alpha autoantibodies in systemic sclerosis-association with pulmonary hypertension and HLA-B35.

Clinical and experimental immunology - 1 Sept 2000

Grigolo B, Mazzetti I, Meliconi R, Bazzi S, Scorza R, Candela M, Gabrielli A, Facchini A

Abstract excerpt

We have previously detected autoantibodies against topoisomerase II alpha (anti-topo II alpha) in sera from patients with idiopathic pulmonary fibrosis. To determine whether anti-topo II alpha is also present in systemic sclerosis (SSc) patients with pulmonary involvement, we screened sera from 92 patients and 34 healthy controls. Presence of anti-topo II alpha was investigated with respect to clinical and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Autoantibodies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Case-Control Studies

Share to DNA Topoisomerases, Type II

Share to HLA-B35 Antigen

Share to Hypertension, Pulmonary

Share to Risk Factors

Share to Scleroderma, Systemic

Source

Open in PubMed Open full text

Identifiers

PMID: 10971522
DOI: 10.1046/j.1365-2249.2000.01320.x
PMCID: PMC1905723

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Anti-topoisomerase II alpha autoantibodies in systemic sclerosis-association with pulmonary hypertension and HLA-B35.PMID 10971522Read ↗

Autoantibodies detectable in the sera of silicosis patients. The relationship between the anti-topoisomerase I antibody response and HLA-DQB1*0402 allele in Japanese silicosis patients.Semantic proximity Read ↗

Disease-related autoantibody profile in patients with systemic sclerosisSemantic proximity Read ↗

Different distribution of HLA class II alleles in anti-topoisomerase I autoantibody responders between silicosis and systemic sclerosis patients, with a common distinct amino acid sequence in the HLA-DQB1 domain.Semantic proximity Read ↗

HLA and clinical associations in systemic sclerosis patients with anti-Th/To antibodies.Semantic proximity Read ↗

MHC class II associations with autoantibody and T cell immune responses to the scleroderma autoantigen topoisomerase I.Semantic proximity Read ↗

Comprehensive Autoantibody Profiles in Systemic Sclerosis: Clinical Cluster AnalysisSemantic proximity Read ↗

HLA and autoimmunity in scleroderma (systemic sclerosis).Semantic proximity Read ↗

Human Leukocyte Antigen and Systemic Sclerosis in Japanese: The Sign of the Four Independent Protective Alleles, DRB1*13:02, DRB1*14:06, DQB1*03:01, and DPB1*02:01.Semantic proximity Read ↗

HLA-DQB1 associations with anti-topoisomerase-1 antibodies in patients with systemic sclerosis and their first degree relatives. United Kingdom Systemic Sclerosis Study Group.Semantic proximity Read ↗

Autoreactive T cells to topoisomerase I in monozygotic twins discordant for systemic sclerosis.Semantic proximity Read ↗

Severe systemic sclerosis with anti-topoisomerase I antibodies is associated with an HLA-DRw11 allele.Semantic proximity Read ↗

Class II HLA associations with autoantibodies in scleroderma: a highly significant role for HLA-DP.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.