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Article

Deficiency of type I interferon contributes to Sle2-associated component lupus phenotypes.

Arthritis and rheumatism - 1 Oct 2005

Li Jianwei, Liu Yang, Xie Chun, Zhu Jiankun, Kreska Desi, Morel Laurence, Mohan Chandra

Abstract excerpt

OBJECTIVE: Studies in mice and humans have implicated type I interferon (IFN-I) in the pathogenesis of lupus. Given that the locus for IFN-I is positioned within the Sle2 murine lupus susceptibility interval on chromosome 4, we undertook this study to investigate whether differences in IFN-I levels might potentially contribute to the phenotypes ascribed to this locus. METHODS: IFN-I, anti-IFN-I, isotype control...

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Share to Antibodies, Antinuclear
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interferon-alpha

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Share to Lupus Erythematosus, Systemic

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Share to Polymorphism, Genetic

Source

Identifiers

PMID: 16200585
DOI: 10.1002/art.21307

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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