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Article

Specification of a DNA replication origin by a transcription complex.

Nature cell biology - 1 Aug 2004

Danis Etienne, Brodolin Konstantin, Menut Sophie, Maiorano Domenico, Girard-Reydet Claire, Méchali Marcel

Abstract excerpt

In early Xenopus development, transcription is repressed and DNA replication initiates at non-specific sites. Here, we show that a site-specific DNA replication origin can be induced in this context by the assembly of a transcription domain. Deletion of the promoter element abolishes site-specific initiation, and its relocalization to an ectopic site induces a new origin of replication. This process does not...

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Identifiers

PMID: 15247921
DOI: 10.1038/ncb1149

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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