Article
RNA polymerase II and III transcription factors can stimulate DNA replication by modifying origin chromatin structures.
Nucleic acids research - 15 Nov 2001
Bodmer-Glavas M, Edler K, Barberis A
Abstract excerpt
Many transcription factors are multifunctional and also influence DNA replication. So far, their mechanism of action has remained elusive. Here we show that a DNA-binding protein could rely on the same biochemical activity that activates transcription to stimulate replication from the yeast chromosomal ARS1 origin. Unexpectedly, the ability to stimulate replication from this origin was not restricted to...
Topics
- Binding Sites
- Chromatin
- Chromosomes, Fungal
- DNA Replication
- DNA-Binding Proteins
- Histones
- Mutation
- Protein Binding
- RNA Polymerase II
- RNA Polymerase III
- Replication Origin
- Saccharomyces cerevisiae Proteins
- Transcription Factors
- Transcription, Genetic