Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chromatin regulates origin activity in Drosophila follicle cells.

Nature - 15 Jul 2004

Aggarwal Bhagwan D, Calvi Brian R

Abstract excerpt

It is widely believed that DNA replication in multicellular animals (metazoa) begins at specific origins to which a pre-replicative complex (pre-RC) binds. Nevertheless, a consensus sequence for origins has yet to be identified in metazoa. Origin identity can change during development, suggesting that there are epigenetic influences. A notable example of developmental specificity occurs in Drosophila, where...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Butyrates
Share to Chorion
Share to Histone Deacetylase 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histone Deacetylase Inhibitors

Share to Hydroxamic Acids

Share to Origin Recognition Complex

Share to Ovarian Follicle

Share to Replication Origin

Source

Identifiers

PMID: 15254542
DOI: 10.1038/nature02694

Genes

ORC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chromatin regulates origin activity in Drosophila follicle cells.PMID 15254542Read ↗

The histone acetyltransferases CBP and Chameau integrate developmental and DNA replication programs in <i>Drosophila</i> ovarian follicle cellsSemantic proximity Read ↗

The Histone Variant H3.3 Is Enriched at Drosophila Amplicon Origins but Does Not Mark Them for Activation.Semantic proximity Read ↗

Analysis of a Drosophila amplicon in follicle cells highlights the diversity of metazoan replication origins.Semantic proximity Read ↗

Su(Hw) primes 66D and 7F Drosophila chorion genes loci for amplification through chromatin decondensation.Semantic proximity Read ↗

Specification of a DNA replication origin by a transcription complex.Semantic proximity Read ↗

Cul4 and DDB1 regulate Orc2 localization, BrdU incorporation and Dup stability during gene amplification in Drosophila follicle cells.Semantic proximity Read ↗

Drosophila follicle cell amplicons as models for metazoan DNA replication: a cyclinE mutant exhibits increased replication fork elongation.Semantic proximity Read ↗

The origin recognition complex is dispensable for endoreplication in Drosophila.Semantic proximity Read ↗

How MCM loading and spreading specify eukaryotic DNA replication initiation sitesSemantic proximity Read ↗

ORC localization in Drosophila follicle cells and the effects of mutations in dE2F and dDP.Semantic proximity Read ↗

Epigenetic regulation affects fertility in <i>Drosophila</i> : toward the production of infertile modelsSemantic proximity Read ↗

Diversity of eukaryotic DNA replication origins revealed by genome-wide analysis of chromatin structure.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.