Article
Functional polymorphisms of UDP-glucuronosyltransferases 1A1, 1A6 and 1A8 are not involved in chronic pancreatitis.
Pharmacogenetics - 1 Jun 2004
Verlaan Mariette, te Morsche René H M, Pap Akos, Laheij Robert J F, Jansen Jan B M J, Peters Wilbert H M, Drenth Joost P H
Abstract excerpt
OBJECTIVES: Chronic pancreatitis (CP) is associated with alcohol abuse, smoking and other dietary or environmental factors. UDP-glucuronosyltransferases (UGTs) are phase II detoxifying enzymes responsible for glucuronidation of various exogenous and endogenous compounds. Genetic variations, resulting in variable rates of glucuronidation, are of toxicological and physiological importance and are frequently...
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