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Article

Glutathione S-transferase Mu null genotype affords protection against alcohol induced chronic pancreatitis.

American journal of medical genetics. Part A - 1 Jul 2003

Verlaan Mariette, te Morsche René H M, Roelofs Hennie M J, Laheij Robert J F, Jansen Jan B M J, Peters Wilbert H M, Drenth Joost P H

Abstract excerpt

Glutathione S-transferases (GSTs) play critical roles in providing protection against electrophiles and products of oxidative stress, by catalysing the formation of glutathione conjugates and by eliminating peroxides. Most extensively studied are four main families of human cytosolic GST: GSTAlpha(A), GSTMu(M), GSTPi(P) and GSTTheta(T). Absence of GSTM1 or GSTT1 can be attributed to absence of the GSTM1 or GSTT1...

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Source

Identifiers

PMID: 12794689
DOI: 10.1002/ajmg.a.20010

Genes

GSTM1
GSTT1
GSTP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Glutathione S-transferase Mu null genotype affords protection against alcohol induced chronic pancreatitis.PMID 12794689Read ↗

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Genetic polymorphisms in phase II metabolizing enzymes in alcoholic and idiopathic chronic pancreatitis: Indian scenario.Semantic proximity Read ↗

Polymorphisms of the glutathione S-transferases mu-1 (GSTM1) and theta-1 (GSTT1) and the risk of advanced alcoholic liver disease.Semantic proximity Read ↗

Meta-analysis: glutathione-S-transferase allelic variants are associated with alcoholic liver disease.Semantic proximity Read ↗

Functional polymorphisms of UDP-glucuronosyltransferases 1A1, 1A6 and 1A8 are not involved in chronic pancreatitis.Semantic proximity Read ↗

Glutathione-S-transferase GST M1 "null" genotype and the risk of alcoholic liver disease.Semantic proximity Read ↗

Genetic polymorphisms of manganese-superoxide dismutase and glutathione-S-transferase in chronic alcoholic pancreatitis.Semantic proximity Read ↗

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Glutathione S-transferase GSTT1 and GSTM1 allozymes: beyond null alleles.Semantic proximity Read ↗

Activity of glutathione S-transferase and its π isoenzyme in the context of single nucleotide polymorphism in the GSTP1 gene (rs1695) and tobacco smoke exposure in the patients with acute pancreatitis and healthy subjects.Semantic proximity Read ↗

Significant association between GSTT1 null genotype and susceptibility to pancreatic cancer.Semantic proximity Read ↗

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