Article
A common variant of PNPLA3 (p.I148M) is not associated with alcoholic chronic pancreatitis.
PloS one - 1 Jan 2012
Rosendahl Jonas, Tönjes Anke, Schleinitz Dorit, Kovacs Peter, Wiegand Johannes, Ruffert Claudia, Jesinghaus Moritz, Schober Robert, Herms Max, Grützmann Robert, Schulz Hans-Ulrich, Stickel Felix, Werner Jens, Bugert Peter, Blüher Matthias, Stumvoll Michael, Böhm Stephan, Berg Thomas, Wittenburg Henning, Mössner Joachim, te Morsche Rene, Derikx Monique, Keim Volker, Witt Heiko, Drenth Joost P H
Abstract excerpt
BACKGROUND: Chronic pancreatitis (CP) is an inflammatory disease that in some patients leads to exocrine and endocrine dysfunction. In industrialized countries the most common aetiology is chronic alcohol abuse. Descriptions of associated genetic alterations in alcoholic CP are rare. However, a common PNPLA3 variant (p.I148M) is associated with the development of alcoholic liver cirrhosis (ALC). Since, alcoholic...
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