Article
Paraoxonase 1-192Q allele is a risk factor for idiopathic chronic pancreatitis.
Molecular diagnosis : a journal devoted to the understanding of human disease through the clinical application of molecular biology - 1 Jan 2005
Verlaan Mariette, Harbers Erik G A, Pap Akos, Jansen Jan B M J, Peters Wilbert H M, Drenth Joost P H
Abstract excerpt
BACKGROUND: The cause of chronic pancreatitis (CP) remains unknown. However, oxidative stress might play a role since recent animal studies have demonstrated that oxygen-free radicals contribute to the pathogenesis of experimental pancreatitis. Human serum paraoxonase (PON1) is an antioxidant enzyme that protects against cellular damage from oxidative stress. Genetic variations resulting in variable activity...
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