Article
UGT1A7 polymorphisms in chronic pancreatitis: an example of genotyping pitfalls.
The pharmacogenomics journal - 1 Feb 2008
te Morsche R H M, Drenth J P H, Truninger K, Schulz H-U, Kage A, Landt O, Verlaan M, Rosendahl J, Macek M, Jansen J B M J, Witt H
Abstract excerpt
UDP-glucuronosyltransferases (UGT) catalyze the glucuronidation of various compounds and thus inactivate toxic substrates. Genetic variations reducing the activity of UGT1A7 have been associated with various gastrointestinal cancers. Most recently, the UGT1A7*3 allele has been reported as a significant risk factor for pancreatic disorders, but we could not confirm these data. This study focused on the possible...
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