Article
Identification of distinct N-terminal truncated forms of prion protein in different Creutzfeldt-Jakob disease subtypes.
The Journal of biological chemistry - 10 Sept 2004
Zanusso Gianluigi, Farinazzo Alessia, Prelli Frances, Fiorini Michele, Gelati Matteo, Ferrari Sergio, Righetti Pier Giorgio, Rizzuto Nicolò, Frangione Blas, Monaco Salvatore
Abstract excerpt
In prion diseases, the cellular prion protein (PrP(C)) is converted to an insoluble and protease-resistant abnormal isoform termed PrP(Sc). In different prion strains, PrP(Sc) shows distinct sites of endogenous or exogenous proteolysis generating a core fragment named PrP27-30. Sporadic Creutzfeldt-Jakob disease (sCJD), the most frequent human prion disease, clinically presents with a variety of neurological...
Topics
- Adult
- Aged
- Binding Sites
- Blotting, Western
- Brain
- Creutzfeldt-Jakob Syndrome
- Detergents
- Electrophoresis, Gel, Two-Dimensional
- Female
- Glycosylation