Article
Codon 129 polymorphism and the E200K mutation do not affect the cellular prion protein isoform composition in the cerebrospinal fluid from patients with Creutzfeldt-Jakob disease.
The European journal of neuroscience - 1 Jun 2010
Schmitz Matthias, Schlomm Markus, Hasan Badrul, Beekes Michael, Mitrova Eva, Korth Carsten, Breil Andreas, Carimalo Julie, Gawinecka Joanna, Varges Daniela, Zerr Inga
Abstract excerpt
The cellular prion protein (PrP(c)) is a multifunctional, highly conserved and ubiquitously expressed protein. It undergoes a number of modifications during its post-translational processing, resulting in different PrP(c) glycoforms and truncated PrP(c) fragments. Limited data are available in humans on the expression and cleavage of PrP(c). In this study we investigated the PrP(c) isoform composition in the...
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