Article
Biochemical fingerprints of prion diseases: scrapie prion protein in human prion diseases that share prion genotype and type.
Journal of neurochemistry - 1 Jan 2005
Pan Tao, Li Ruliang, Kang Shin-Chung, Pastore Manuela, Wong Boon-Seng, Ironside James, Gambetti Pierluigi, Sy Man-Sun
Abstract excerpt
The phenotype of human prion diseases is influenced by the prion protein (PrP) genotype as determined by the methionine (M)/valine (V) polymorphism at codon 129, the scrapie PrP (PrPSc) type and the etiology. To gain further insight into the mechanisms of phenotype determination, we compared two-dimensional immunoblot profiles of detergent insoluble and proteinase K-resistant PrP species in a type of sporadic...
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