Article
Two-dimensional mapping of three phenotype-associated isoforms of the prion protein in sporadic Creutzfeldt-Jakob disease.
Electrophoresis - 1 Jan 2002
Zanusso Gianluigi, Righetti Pier Giorgio, Ferrari Sergio, Terrin Liliana, Farinazzo Alessia, Cardone Franco, Pocchiari Maurizio, Rizzuto Nicola, Monaco Salvatore
Abstract excerpt
Transmissible spongiform encephalopathies (TSE), or prion diseases, are mammalian neurodegenerative disorders characterized by a conformational modification of the host-encoded prion protein (PrP(C)) into an isoform which is detergent-insoluble and partially resistant to protease treatment (PrP(Sc)). Distinct types of PrP(Sc), differing in conformation and variation in the relative amount of their glycoforms,...
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