Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Distinct patterns of natural selection in the reverse transcriptase gene of HIV-1 in the presence and absence of antiretroviral therapy.

Virology - 1 Aug 2004

de S Leal Elcio, Holmes Edward C, Zanotto Paolo M de A

Abstract excerpt

The emergence of human immunodeficiency virus (HIV) drug-resistant mutations during antiretroviral therapy is explained by either the preexistence of low-frequency-resistant strains before the start of therapy or by the selection of unsuppressed resistant strains during therapy. We used pairwise and maximum likelihood analyses of the ratio of nonsynonymous to synonymous substitutions per site (d(N)/d(S)) to study...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-HIV Agents
Share to Brazil
Share to Codon

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Didanosine

Share to Drug Resistance, Viral

Share to Genes, Viral

Share to HIV Reverse Transcriptase

Share to Likelihood Functions

Source

Identifiers

PMID: 15246258
DOI: 10.1016/j.virol.2004.04.004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Distinct patterns of natural selection in the reverse transcriptase gene of HIV-1 in the presence and absence of antiretroviral therapy.PMID 15246258Read ↗

Parallel evolution of drug resistance in HIV: failure of nonsynonymous/synonymous substitution rate ratio to detect selection.Semantic proximity Read ↗

Analysis of selection pressure and mutational pattern of HIV type 1 reverse transcriptase region among treated and nontreated patients.Semantic proximity Read ↗

Retracing the Evolutionary Pathways of Human Immunodeficiency Virus Type 1 Resistance to Protease Inhibitors: Virus Fitness in the Absence and in the Presence of DrugSemantic proximity Read ↗

Nucleotide substitution patterns can predict the requirements for drug-resistance of HIV-1 proteins.Semantic proximity Read ↗

Positive selection detection in 40,000 human immunodeficiency virus (HIV) type 1 sequences automatically identifies drug resistance and positive fitness mutations in HIV protease and reverse transcriptase.Semantic proximity Read ↗

A model of directional selection applied to the evolution of drug resistance in HIV-1.Semantic proximity Read ↗

Loss and recovery of genetic diversity in adapting populations of HIV.Semantic proximity Read ↗

Constrained patterns of covariation and clustering of HIV-1 non-nucleoside reverse transcriptase inhibitor resistance mutationsSemantic proximity Read ↗

Predominance of positive epistasis among drug resistance-associated mutations in HIV-1 proteaseSemantic proximity Read ↗

Identification of biased amino acid substitution patterns in human immunodeficiency virus type 1 isolates from patients treated with protease inhibitors.Semantic proximity Read ↗

Short communication: Nucleotide variation and positively selected sites in HIV type 1 reverse transcriptase among heterosexual transmission pairs.Semantic proximity Read ↗

Adaptation to different human populations by HIV-1 revealed by codon-based analyses.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.