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Article

Nucleotide substitution patterns can predict the requirements for drug-resistance of HIV-1 proteins.

Antiviral research - 1 Jun 1996

Keulen W, Boucher C, Berkhout B

Abstract excerpt

The enzyme reverse transcriptase (RT) plays a fundamental role in the replication of the human immunodeficiency virus type 1 (HIV-1) and several antiviral agents that target this key enzyme have been developed. Unfortunately, treatment of patients with RT inhibitors results in the appearance of drug-resistant variants with specific mutations in the RT protein. We hypothesized that if "difficult' resistance...

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PMID: 8793008
DOI: 10.1016/0166-3542(96)00944-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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