Article
A model of directional selection applied to the evolution of drug resistance in HIV-1.
Molecular biology and evolution - 1 Apr 2007
Seoighe Cathal, Ketwaroo Farahnaz, Pillay Visva, Scheffler Konrad, Wood Natasha, Duffet Rodger, Zvelebil Marketa, Martinson Neil, McIntyre James, Morris Lynn, Hide Winston
Abstract excerpt
Understanding how pathogens acquire resistance to drugs is important for the design of treatment strategies, particularly for rapidly evolving viruses such as HIV-1. Drug treatment can exert strong selective pressures and sites within targeted genes that confer resistance frequently evolve far more rapidly than the neutral rate. Rapid evolution at sites that confer resistance to drugs can be used to help...
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