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Article

Constrained patterns of covariation and clustering of HIV-1 non-nucleoside reverse transcriptase inhibitor resistance mutations

12 May 2010

Abstract excerpt

OBJECTIVES: We characterized pairwise and higher order patterns of non-nucleoside reverse transcriptase inhibitor (NNRTI)-selected mutations because multiple mutations are usually required for clinically significant resistance to second-generation NNRTIs. PATIENTS AND METHODS: We analysed viruses from 13 039 individuals with sequences containing at least one of 52 published NNRTI-selected mutations, including...

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PMID: 20462946
DOI: 10.1093/jac/dkq140

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