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Article

En1 and Wnt7a interact with Dkk1 during limb development in the mouse.

Developmental biology - 1 Aug 2004

Adamska Maja, MacDonald Bryan T, Sarmast Zubair H, Oliver Edward R, Meisler Miriam H

Abstract excerpt

Wnt signaling plays an essential role in induction and development of the limb. Missing digits are one consequence of the reduced Wnt signaling in Wnt7a null mice, while extra digits result from excess Wnt signaling in mice null for the Wnt antagonist Dkk1. The extra digits and expanded apical ectodermal ridge (AER) of Dkk1-deficient mice closely resemble En1 null mice. To evaluate the in vivo interaction between...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15242796
DOI: 10.1016/j.ydbio.2004.04.026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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