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Article

The expression of the amyloid precursor protein (APP) is regulated by two GC-elements in the promoter

1 Jan 1992

Abstract excerpt

The structure of the promoter of the human APP gene resembles that of housekeeping genes, with the presence of a GC-rich region and the lack of a canonical TATA box. Since analysis of the expression of the APP gene, especially at the transcriptional level, might reveal factors or elements, which influence amyloid formation in Alzheimer's disease, a 5' deletion analysis of the APP promoter was performed, leading...

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PMID: 1738605
DOI: 10.1093/nar/20.1.63

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