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Article

Interdependent SMAD and JNK Signaling in Transforming Growth Factor-β-mediated Transcription

1 Dec 1999

Abstract excerpt

SMAD and JNK cascades are essential components of the transforming growth factor-beta (TGF-beta) signaling machinery and are implicated in common transcriptional responses. However, the relationship of these pathways to one another downstream of the TGF-beta receptor complex is unknown. We show that JNK is rapidly activated by TGF-beta in a SMAD-independent manner and phosphorylates Smad3 outside its -SSXS motif....

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PMID: 10601313
DOI: 10.1074/jbc.274.52.37413

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