Article

Human Papilloma Virus does not fully inactivate p53 cellular activity in HNSCC

2025-02-14

Abstract excerpt

Head and neck squamous cell carcinoma (HNSCC) is a major global health challenge. Inactivation of the tumor suppressor p53 is the most frequent molecular event in this malignancy. p53 inactivation occurs either through TP53 mutations in human papilloma virus (HPV)-negative cases or via HPV-mediated p53 degradation in HPV-positive (HPV+) cases, where most tumors retain a wild-type (WT) TP53 allele. This underscor...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8615f615-2399-5f4a-8574-c16fd0c92847
DOI: 10.1101/2025.02.11.637252

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Human Papilloma Virus does not fully inactivate p53 cellular activity in HNSCCDOI 10.1101/2025.02.11.637252Read

Human Papilloma Virus Does Not Fully Inactivate p53 Cellular Activity in HNSCC.Semantic proximity Read

Molecular landscape of head and neck cancer and implications for therapySemantic proximity Read

Molecular Insights into HPV-Driven Head and Neck Cancers: From Viral Oncoproteins to Precision TherapeuticsSemantic proximity Read

Human papillomavirus in head and neck cancer: its role in pathogenesis and clinical implications.Semantic proximity Read

Advances in human papillomavirus detection and molecular understanding in head and neck cancers: Implications for clinical managementSemantic proximity Read

Human Papillomavirus Drives Tumor Development Throughout the Head and Neck: Improved Prognosis Is Associated With an Immune Response Largely Restricted to the OropharynxSemantic proximity Read

Genomic insights into head and neck cancerSemantic proximity Read

Genomic Enrichment and Functional Impact of TP53 and CYLD Alterations in Recurrent and Metastatic HPV-Associated Head and Neck Cancer.Semantic proximity Read

Molecular mechanisms of human papillomavirus-related carcinogenesis in head and neck cancerSemantic proximity Read

TP53 mutations in head and neck cancer.Semantic proximity Read

Molecular Aspects of Head and Neck Cancer Therapy.Semantic proximity Read

Clinical, morphologic and molecular heterogeneity of HPV-associated oropharyngeal cancerSemantic proximity Read