Article
Involvement of intact HPV16 E6/E7 gene expression in head and neck cancers with unaltered p53 status and perturbed pRb cell cycle control.
Oncogene - 28 Feb 2002
Wiest Tina, Schwarz Elisabeth, Enders Christel, Flechtenmacher Christa, Bosch Franz X
Abstract excerpt
We have identified parameters which define a causal role of HPV16 in head and neck cancer. Twenty-eight tumours which were typed positive for HPV16 DNA, were comprehensively analysed for expression of the viral oncogenes E6 and E7, the status of the p53 gene, and the protein status of pRb and p16...
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