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Article

Human papillomavirus type 16 E6 and E7 genotypes in head-and-neck carcinomas.

Oral oncology - 1 May 2004

Hoffmann Markus, Lohrey Claudia, Hunziker Andreas, Kahn Tomas, Schwarz Elisabeth

Abstract excerpt

Human papillomavirus type 16 (HPV16) is associated with squamous cell carcinomas of the head and neck (HNSCC) particularly from the Waldeyer's tonsillar ring. A causal role of HPV16 in carcinogenesis is linked to the activity of the viral oncoproteins E6 and E7 which inactivate the cellular tumor suppressors p53 and pRB, respectively. Lack of E6 expression in HPV16-positive HNSCC has been reported, in some cases...

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Share to Carcinoma, Squamous Cell
Share to DNA, Neoplasm
Share to Head and Neck Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphatic Metastasis

Share to Oncogene Proteins, Viral

Share to Papillomaviridae

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Source

Identifiers

PMID: 15006625
DOI: 10.1016/j.oraloncology.2003.10.011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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