Article
Evidence for a causal association between human papillomavirus and a subset of head and neck cancers.
Journal of the National Cancer Institute - 3 May 2000
Gillison M L, Koch W M, Capone R B, Spafford M, Westra W H, Wu L, Zahurak M L, Daniel R W, Viglione M, Symer D E, Shah K V, Sidransky D
Abstract excerpt
BACKGROUND: High-risk human papillomaviruses (HPVs) are etiologic agents for anogenital tract cancers and have been detected in head and neck squamous cell carcinomas (HNSCCs). We investigated, retrospectively, an etiologic role for HPVs in a large series of patients with HNSCC. METHODS: Tumor tissues from 253 patients with newly diagnosed or recurrent HNSCC were tested for the presence of HPV genome by use of...
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